Using the Windows To Go or boot from VHD features

Since Windows 8.1, there have been no major improvements done to the Windows To Go feature. Since 8.0, there were problems in performing an in-place upgrade, and these limitations still persist. So if you go with Windows 10 CB/CBB in a Windows To Go scenario, you will end up in a wipe and load one to two times a year for your USB media. The only way to circumvent this problem is to use the LTSB version on Windows To Go media, but with all the limitations and problems of LTSB.

Boot from VHD in terms of saving space was replaced by a better feature called Compact OS. So if you have been doing boot from VHD only for space savings, you should do a wipe and load and go with Compact OS in future, which is fully in-place capable. If you've used boot from VHD for separating different (test) installations and want to use this feature in future versions, you need to do a wipe and load every time.