The distemper was not only fatal in its termination, but loathsome in its progress; for the blood of those affected being poisoned by atmospheric contagion, bred venom in the body, which burst forth into nauseous sores and uncleanness; or otherwise preyed with more rapid fatality internally, in some cases causing death before its victims were assured of disease. Nor did it spare the young and robust any more than those weak of frame or ripe with years, but attacking stealthily, killed speedily. It was indeed the "pestilence that walketh in darkness, and the destruction that wasteth in the noonday." In the month of May, when it was yet uncertain if the city would be spared even in part, persons of position and wealth, and indeed those endowed with sufficient means to support themselves elsewhere, resolved to fly from the capital; whilst such as had neither home, friends, nor expectation of employment in other places, remained behind. Accordingly great preparations were made by those who determined on flight; and all day long vast crowds gathered round my lord mayor's house in St. Helen's, Bishopsgate, seeking certificates of health, so that for some weeks it was difficult to reach his door for the throng that gathered there, as is stated by John Noorthouck. Such official testimonies to the good health of those leaving London had now become necessary; for the inhabitants of provincial towns, catching the general alarm, refused to shelter in their houses, or even let pass through their streets, the residents of the plague-stricken city, unless officially assured they were free from the dreaded distemper.

Nay, even with such certificates in their possession, many were refused admittance to inns, or houses of entertainment, and were therefore obliged to sleep in fields by night, and beg food by day, and not a few deaths were caused by want and exposure.

And now were the thoroughfares of the capital crowded all day long with coaches conveying those who sought safety in flight, and with waggons and carts containing their household goods and belongings, until it seemed as if the city mould be left without a soul. Many merchants and shipowners together with their families betook themselves to vessels, which they caused to be towed down the river towards Greenwich, and in which they resided for months; whilst others sought refuge in smacks and fishing-boats, using them as shelters by day, and lodging on the banks by night. Some few families remaining in the capital laid in stores of provisions, and shutting themselves up securely in their houses, permitted none to enter or leave, by which means some of them escaped contagion and death. The court tarried until the 29th of June, and then left for Hampton, none too soon, for the pestilence had reached almost to the palace gates. The queen mother likewise departed, retiring into France; from which country she never returned.