Matilda"Wheezer"Choi,theasthmaticwhocanflyandkickbuttcourtesyofhernanobyte-enhancedinhalers,lovesprowrestlingandhatesanything"girlie."Maybethat'sbecauseshegrewupwithsixbrothers—ormaybeit'sbecauseherhomelifehasbecomeabattlezoneintheconflictbetweenherparents.UnfortunatelyforWheezer,whenaformermemberofNERDSturnedvillaingetsextensiveplasticsurgeryinordertobecomeacheerleader,Matildamustswallowherpridetosuccessfullyinfiltratethesquad.Thenewestsupervillain,GerdieBaker,assistedbythecriminalmastermindSimon,hascreatedadevicethatopensportalstootherworlds,whichsheandtheothercheerleadershavebeenpillaging.Butthealternaterealitiesarestartingtogetawfullyclosetogether,soit'suptoWheezerandtheNERDStostopthecheerleadersbeforetheworldscollide.